Abstract
The progression of ‘naı̈ve’ and ‘memory’ T-cells and the T-cell receptor Vβ (TCR Vβ) repertoire dynamics within the peripheral CD4 + T-cell compartment were studied in individuals following HIV seroconversion. Profound TCR Vβ repertoire perturbations were observed within the CD4 + T-cell pool in treatment-naive patients regardless of their levels of viremia during the first 6–8 months after seroconversion. The ratio of ‘naı̈ve’ to ‘memory’ CD4 + T-cells as well as the TCR Vβ repertoire dynamics did not appear to correlate with absolute numbers of CD4 + T-cells.
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