NaV1.7 as a pain target - From gene to pharmacology.

Abstract

Na(V)1.7, a subtype of the voltage-gated sodium channel family that is highly expressed in peripheral sensory neurons, remains one of the most promising targets for the treatment of pain. However, despite compelling genetic evidence supporting a key role for Na(V)1.7 in regulating excitability of peripheral sensory neurons, the development of truly subtype-selective inhibitors has been challenging. Here, we discuss complexities surrounding targeting Na(V)1.7 pharmacologically for treatment of pain and explore future opportunities for development of effective analgesic Na(V)1.7 inhibitors. (C) 2016 Elsevier Inc. All rights reserved.