Abstract
The aim of this chapter is to review esophageal and gastric diseases and disorders that are the underlying mechanisms for unexplained nausea and vomiting. Nausea and vomiting are usually attributed to stomach disorders. However, nausea can also be due to esophageal diseases. Acid reflux events correlate with reports of nausea in patients with unexplained nausea who had normal gastric emptying and normal gastric myoelectrical activity (GMA). Nausea and vomiting are associated with stomach disorders such as gastroparesis, gastric dysrhythmias, and other gastric neuromuscular abnormalities which will be described below. By determining the pathophysiological pathways that drive the symptoms of nausea, specific and rational treatments can be designed.
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