Abstract
The potent immunosuppressive agent Cyclosporin A (CyA) causes a spectrum of toxicological effects in rats, of which the most striking is weight loss. Pair-feeding experiments have shown that this is caused, in part, by a short period of anorexia. However, even when the food intake has become normal the rats receiving CyA fail to gain weight. That CyA at the doses used causes increased protein catabolism is also indicated by a fall in serum albumin and a marked rise in blood urea unaccompanied by a corresponding rise in creatinine. CyA is mildly and reversibly hepatotoxic and there is slight nephrotoxicity in the rat on the basis of histology and small elevations in creatinine.
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