Abstract
In the unanesthetized cat, TRH was injected into the cerebral ventricles (ICV) through chronically implanted cannulae and the nature of the evoked salivation was investigated. TRH injected in doses from 0.1 to 1.0 mg evoked salivation which was not dose-dependent. The antimuscarinic drug atropine as well as the ganglionic blocking agent mecamylamine injected also ICV prevented the salivation induced by ICV TRH. On the other hand, virtually no effect on the TRH—salivation was induced by the following drugs injected ICV: alpha and the beta adrenergic blocking agents, yohimbine and propranolol; dopamine antagonist, chlorpromazine; 5-hydroxytryptamine antagonist, methysergide; and the antihistamine, antazoline. Further, in cats pretreated with ICV reserpine and 6-hydroxydopamine, but not with ICV 5,6-dihydroxytryptamine and hemicholinium, the salivation caused by ICV TRH was abolished. It is concluded that central cholinoceptive and catecholaminergic mechanisms are involved in the salivation induced by ICV TRH.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
