Abstract
l-leucine uptake into full-grown oocytes of Xenopus laevis is a saturable process which is Na + dependent and presumably coupled to Na + gradient. Our results indicate that progesterone (10 −6 M) blocks abruptly, around the germinal vesicle breakdown, the saturable transport of l-leucine. p- Chloromercuribenzoate (10 −4 M) induces maturation and after a short lag of time strongly inhibits l-leucine uptake. Cycloheximide prevents progesterone-induced maturation and permeability changes.
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