Abstract
Due to the controversy in the recent literature concerning the T-cell nature of the neonatal mouse splenic suppressor cell, we have reexamined the nature of these cells at different stages after birth. With the use of monoclonal anti-Thy antibody we can detect T-cell products on spleen suppressor cells from BDF 1 mice at 3, 4, 5, 6, and 7 days of age. The suppressor cells are assayed by their ability to inhibit mixed-lymphocyte reactivity, which is an in vitro example of cell-mediated immunity. The neonatal spleen suppressor cells also carry products of the Ly 1 and I-J locus. Neonatal thymectomy results in a premature decrease of suppressor cell activity. These data suggest that the mouse neonatal splenic suppressor cell is a short-lived Ly 1 +, I-J + T cell.
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