Abstract
Successive injections of estradiol benzoate (EB) given to intact male rats for the first 30 days of postnatal life (the daily dose was increased with age, 1 μg being injected during the first 10 days of life, 2 μg during the next 10 days, and 4 μg from days 21 to 30) induced metaplasia (squamous stratification and cornification) in the coagulating gland epithelium in 45.5% of the animals. When EB was given to neonatally castrated male rats, the incidence of metaplasia was increased to 100%. This metaplasia was not reversible and was quite hyperplastic long after the treatment had been stopped. However, the development of metaplasia was completely inhibited by injections of testosterone propionate (50 μg for the first 15 days and 100 μg for the second 15 days, respectively) given to neonatally castrated male rats concurrently with EB. (Endocrinology 86: 918, 1970)
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