Abstract
Objective: Magnetite (Fe3O4) nanoparticles (NPs) have gained considerable attention in the Biomedical filed. Evolution of new magnetic material based on the transition metal-doped magnetite has become the subject of increasing research interest. The main aim of the current investigation was to improve the diabetic potential, optical, magnetic, structural properties of magnetite nanoparticles and hence Fe3O4 NPs were doped with a divalent transition element such as Zinc.
 Methods: Zinc doped magnetite nanoparticles (Zn-Fe3O4 NPs) were obtained through Co-precipitation methods using aqueous plant extract of Andrographis paniculata acted as an efficient stabilizer and a reducing agent. The structure, morphology, crystalline, optical and magnetic property of synthesized Zn-Fe3O4 NPs were evaluated by X-ray diffraction (XRD), Scanning electron microscopy with Energy dispersive x-ray spectroscopy(SEM-EDX), Fourier transform infrared spectroscopy (FTIR), Ultraviolet-Visible (UV-Vis) Spectrophotometer and Vibrating scanning magnetometer (VSM).
 Results: In XRD analysis, the average crystallite size of the synthesized Zn-Fe3O4 NPs was found to be 5 nm exhibiting super paramagnetic behavior, which composes it an appealing possibility for biomedicines. The Zn-Fe3O4 NPs had strongly inhibited the alpha (α)-amylase enzyme and had proved their therapeutic role.
 Conclusion: In conclusion, Zn-Fe3O4 NPs is an excellent anti-diabetic agent to control type 2 diabetes mellitus.
Highlights
Iron oxide nanoparticles (IONPs) are widely used in bioremediation systems because of their cost efficiency, magnetic strength, biocompatibility, easy water separation and surface modifiability
Extinction spectra of Andrographis paniculata and synthesized Zn-Fe3O4 Nps are depicted in fig
Fourier transform infrared spectroscopy (FTIR) spectral data indicated that the phytochemical constituents found in the Andrographis paniculata extract acts as an efficient stabilizer and reducing agent for the synthesized Zn-Fe3O4 NPs
Summary
Iron oxide nanoparticles (IONPs) are widely used in bioremediation systems because of their cost efficiency, magnetic strength, biocompatibility, easy water separation and surface modifiability. Maghemite (γ-Fe2O3), Magnetite (Fe3O4) and hematite (α-Fe2O3) are the most common IONPs found in nature [1]. Magnetite (Fe3O4) is the strongest magnetic mineral on earth [2]. Fe3O4 NPs (magnetite nanoparticles) have a property that is ferromagnetic at RT (Room temperature) [3]. The magnetic behavior of magnetite nanoparticles depends largely on the preparation methods. The crystallite size and surface morphology of Fe3O4 crystal play a crucial role, which influences the magnetic properties of Fe3O4 NPs [4, 5]
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