Natural Surfactant Mediated Synthesis of 4-Aryl Substituted 3,4-Dihydropyrimidinones

Abstract

Present work describes the synthesis of 4-aryl substituted 3,4-dihydropyrimidinones (DHPMs) using aqueous extract of pericarp of Sapindus trifoliatus fruit as a green catalyst. The reaction is a one-pot reaction, similar to classical Biginelli reaction employing an aromatic aldehyde, urea and active methylene compound (ethyl acetoacetate) as substrates. Desired DHPMs were yielded within 2 h at room temperature. The key advantage of the present strategy was its low dependence on organic solvents as green synthesis.