NATURAL RESISTANCE OF RODNIK CROSS RABBITS UNDER EXPERIMENTAL SEPSIS CONDITIONS CAUSED BY A STREPTOCOCCUS PYOGENES

Abstract

Оn the basis of the department of experimental rabbit breeding of the FGBNU NIIPZK, an interbreed meat cross of the Spring rabbit was created with the participation of three breeds: the white giant, the Soviet chinchilla and the California. The new cross is distinguished by its fertility and precocity, significantly exceeding its peers of the original breeds in meat productivity. An important task was to study the biological features of the new cross, the factors of non-specific protection of its body. The article presents data on the study of the nonspecific resistance of the Spring cross and the source rocks in the conditions of experimental sepsis caused by Streptococcus pyogenes. Experimental infection of rabbits of the Rodnik cross and the original breeds with the pathogen at a dose of LD50 was carried out, and the hematological parameters of blood, bactericidal and lysozyme activity of blood serum were studied in a comparative aspect, the survival rate of rabbits after infection was estimated, pathoanatomical and histological changes in the organs and tissues of infected animals were studied, microbiological studies were conducted to isolate the pathogen from the blood and internal organs. According to the results of the conducted studies, it was found that rabbits of the Spring cross have a higher safety after infection, in comparison with the original breeds. In the histological examination of the internal organs, the pathological changes in the new cross are less pronounced. The study of the qualitative and quantitative characteristics of the shaped blood elements, as well as the lysozyme and bactericidal activity of blood sera, allows us to conclude that the rabbits of the cross Spring have a higher resistance and reactivity of the body, compared to the original breeds.