Abstract
Chemical investigation of the methanol crude extract of dried flower buds of Syzygium aromaticum (Myrtaceae) resulted in the isolation of seven known compounds; oleanolic acid (1), lignoceric acid (2), β-sitosterol (3), heneicosanoic acid (4), 5-hydroxy-7-methoxy-2-methylchromone (5), 5-hydroxy-7-methoxy-2,8-dimethylchromone (6) and vanillin (7). Their structures were elucidated using one-dimensional NMR spectroscopy and comparison with literature data. The crude extract, and compounds 1-6, revealed significant anticonvulsant activities against seizures induced by picrotoxin, pentylenetetrazole and bicuculline, respectively in mice. Compound 3 produced 100% protection, compound 2, and 5; on the other hand, each offered 83.33%, while the lowest protection came from compounds 1, 4, and 6 (16.66 – 50 00 %). This is the first report on the anticonvulsant activity of these isolated compounds, and the first report on the isolation of compounds 2, 4, 5, 6, and 7 from Syzygium aromaticum.
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