Abstract
The genus Tephrosia, belonging to the Leguminosae family, is a large pantropical genus of more than 350 species, many of which have important traditional uses in agriculture. This review not only outlines the source, chemistry and biological evaluations of natural products from the genus Tephrosia worldwide that have appeared in literature from 1910 to December 2013, but also covers work related to proposed biosynthetic pathways and synthesis of some natural products from the genus Tephrosia, with 105 citations and 168 new compounds.
Highlights
The genus Tephrosia, belonging to the Leguminosae family, is a large pantropical genus of more than 350 species, many of which have important traditional uses [1,2]
(+)-Tephrorins A (49) and B (50), and (+)-tephrosone (138) isolated from T. purpurea were evaluated for their potential cancer chemopreventive properties using a cell-based quinone reductase induction assay [4]. 7,4'-dihydroxy-3',5'-dimethoxyisoflavone (94), and (+)-tephropurpurin (139), were obtained as active compounds from T. purpurea, using a bioassay based on the induction of quinone reductase (QR) activity with cultured Hepa 1c1c7 mouse hepatoma cells [5]
Plants of the genus Tephrosia have important traditional uses in agriculture, because they possess the bioactivity of phytoalexins
Summary
The genus Tephrosia, belonging to the Leguminosae family, is a large pantropical genus of more than 350 species, many of which have important traditional uses [1,2]. Molecules 2014, 19 has been studied extensively, indicating that chemical constituents and extracts of the genus Tephrosia exhibited diverse bioactivities, such as insecticidal [11], antiviral [12], antiprotozoal [13], antiplasmodial [14] and cytotoxic [15] activities. The reviews on natural products isolated from the genus Tephrosia are limited [16]. To gain a comprehensive and systematic understanding of this genus, this review outlines the chemistry, proposed biosynthetic pathways, synthesis, and biological evaluations of natural products from the genus Tephrosia worldwide that have appeared in literature from 1971 to December 2013, with 105 citations and 168 new compounds from them
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