Abstract
The Brazilian marine biodiversity represents a unique, yet underexplored resource of biologically active compounds. This review provides an analysis of the development of marine natural products chemistry in Brazil within the period comprised between 2004 and 2017. Emphasis is directed towards marine invertebrate and marine microorganisms metabolites, including isolation, structure analysis, biosynthesis, bioactivities and total synthesis. An overview of the research on marine natural products by Brazilian researchers is also discussed, as well as perspectives for the development of the chemistry of marine natural products in Brazil.
Highlights
The chemistry of natural products is a science well established in Brazil, spanned over 60 years and all over the country
From the beginning of the 21st century there has been a substantial growth of research on microbial natural products by Brazilian researchers,1 and on marine natural products as well
The interest of Brazilian natural product chemists to investigate other sources than plants for the isolation of secondary metabolites are consequential to the chemical diversity of marine and microbial organisms
Summary
The chemistry of natural products is a science well established in Brazil, spanned over 60 years and all over the country. Most of Brazilian natural product researchers devote efforts to the investigation of plant metabolites. The interest of Brazilian natural product chemists to investigate other sources than plants for the isolation of secondary metabolites are consequential to the chemical diversity of marine and microbial organisms. If the sciences of investigating natural products have expanded to unexpected boundaries in a very impressive rate since the advent of genomic tools, there is no need to say that much more remains to be done, exploring new biological sources for the discovery of secondary metabolites. The lack of expertise on the use of genomic tools for the investigation of secondary metabolism is critical This is a severe gap that must be faced in the current education of graduate students involved in natural products chemistry projects. A special issue of the same journal on marine natural products has been published in 2015.10 Publications dealing with crude extracts or with only partially identified, bioactive or not, chemical entities or even primary metabolites, are not included as well
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