Natural Products Could be a Promising Remedy against Biofilm-Forming Bacteria

Abstract

A biofilm is a typical form of naturally occurring bacterial development. Biofilm development could be responsible for developing resistance to harmful environmental conditions, such as developing immunity to antibiotics, medicine and other antibacterial agents (e.g., methicillin, vancomycin, etc). The quorum sensing (QS) process is essential for biofilm development and for preserving environmental equilibrium when bacterial numbers increase. Finding novel antibacterial medications that can regulate the development and expansion of biofilms is imperative because these structures are closely related to the appearance of multidrug and extended drug (e.g., tuberculosis) resistance and infectious illnesses. Natural plant-based chemicals have been found in an increasing amount of studies over the past 20 years to have antibacterial and chemo-preventive properties in the parameter of biofilm growth. The present article will include some herbs with unknown bioactive ingredients or unclear processes, as well as current findings on the identification of natural anti-biofilm chemicals from plants with known molecular addresses or mechanisms. The authors are also focused on developing techniques for locating and isolating naturally occurring anti-biofilm agents. Anti-biofilm treatments awaiting clinical trials are also reviewed. The currently identified natural anti-biofilm compounds are auspicious and may present novel therapeutic strategies for biofilm-associated illnesses