Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a global pandemic and is posing a serious challenge to mankind. As per the current scenario, there is an urgent need for antiviral that could act as a protective and therapeutic against SARS-CoV-2. Previous studies have shown that SARS-CoV-2 is much similar to the SARS-CoV bat that occurred in 2002-03. Since it is a zoonotic virus, the exact source is still unknown, but it is believed bats may be the primary reservoir of SARS-CoV-2 through which it has been transferred to humans. In this review, we have tried to summarize some of the approaches that could be effective against SARS-CoV-2. Firstly, plants or plant-based products have been effective against different viral diseases, and secondly, plants or plant-based natural products have the minimum adverse effect. We have also highlighted a few vitamins and minerals that could be beneficial against SARS-CoV-2.
Highlights
Coronaviruses under the realm of Riboviria belongs to the order Nidovirales, suborder cornidovirinea, family Coronoviridae [1]
The two epidemics due to coronavirus have already occurred that were due to SARSCoV and the Middle East respiratory syndrome (MERS) and both have been the major cause of pneumonia in humans [4]
Different antivirals that have been previously used against SARS, MERS, and influenza have been evaluated alone or in combination, but still, no fruitful response has been achieved
Summary
Coronaviruses under the realm of Riboviria belongs to the order Nidovirales, suborder cornidovirinea, family Coronoviridae [1]. The major amino acid residue of SARS-CoV-2 in the receptor-binding domain is Gln-493, which favors the attachment of spike protein S with human cells with the lungs the attachment results in respiratory infections in humans [11,12]. The receptor-binding domain (RBD) is located in the S1 region of SARS-CoV and the attachment of the human host cell with the virus is mediated by the RBD protein of the RBD domain with the angiotensinconverting enzyme (ACE-2) as a receptor similar to the one required by SARS-CoV [15,16]. We have tried to highlight the use of medicinal plants against different viral diseases including SARS-CoV-2, and the possible factors (vitamins and minerals) that could be helpful against SARS-CoV-2
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