Abstract
Coronavirus disease 2019 (COVID-19) is a new and severe infectious disease and new global disaster and is spreading rapidly worldwide. Natural products have a long history and have been widely used to treat various acute, chronic, and even life-threatening diseases worldwide. However, the natural products have reduced bioavailability and availability as they have poor kinetic properties, such as large molecular weight, inability to cross lipid membranes, and weak absorption ability. With the rapid development of nanotechnology, using novel nanotechnology in conjunction with natural products can effectively eliminate the molecular restriction of the entry of nanoproducts into the body and can be used to diagnose and treat various diseases, including COVID-19, bringing new strategies and directions for medicine. This article reviews the role and implementation of natural products against COVID-19 based on nanotechnology.
Highlights
It has been longer than 2 years since the coronavirus disease 2019 (COVID-19) outbreak, which continues to affect human social and economic life in more than 200 countries and regions around the world (Li et al, 2020; Abu-Raddad et al, 2021; Chen B. et al, 2021; Berwanger, 2021)
Some concerns regarding chloroquine remain due to the side effects caused by the drug dosage, the subsequent optimization of loading based on nanotechnology will likely result in improved functionality and efficacy of chloroquine or chloroquine in the treatment of COVID-19 [Table 1(Borba et al, 2020; Duvignaud et al, 2020; Group et al, 2020; Liu et al, 2020; Panda et al, 2020; Tirupakuzhi Vijayaraghavan et al, 2020; Weehuizen and Hoepelman, 2020; Abd-Elsalam et al, 2021; Gautret et al, 2021; Rea-Neto et al, 2021; Thakar et al, 2021)]
The present review focuses on recent progress in the application of some important natural products
Summary
It has been longer than 2 years since the coronavirus disease 2019 (COVID-19) outbreak, which continues to affect human social and economic life in more than 200 countries and regions around the world (Li et al, 2020; Abu-Raddad et al, 2021; Chen B. et al, 2021; Berwanger, 2021). The application and research of natural products has undergone a long development process from the initial drug compound formulation to the isolation and extraction of highly effective compounds with therapeutic potential from plants and animals (Devi et al, 2010).
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