Abstract
Marine sponges are a very attractive and rich source in the production of novel bioactive compounds. The sponges exhibit a wide range of pharmacological activities. The genus Amphimedon consists of various species, such as viridis, compressa, complanata, and terpenensis, along with a handful of undescribed species. The Amphimedon genus is a rich source of secondary metabolites containing diverse chemical classes, including alkaloids, ceramides, cerebrososides, and terpenes, with various valuable biological activities. This review covers the literature from January 1983 until January 2018 and provides a complete survey of all the compounds isolated from the genus Amphimedon and the associated microbiota, along with their corresponding biological activities, whenever applicable.
Highlights
The broadness in the discovery of natural marine products have increased over the last two decades with the number of new compounds discovered per year increasing [1]
Amphitoxin [26] was isolated from different marine sponges belonging to the order microorganisms, Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Cryptococcus neoformans, Haplosclerida, which is found in relatively high quantities in extracts of Amphimedon compressa, collected near the coast of San Salvador Island
It is similar in structure to a polymeric pyridinium alkaloid, which has recently been isolated which is found in relatively high quantities in extracts of Amphimedon compressa, collected near the from a sponge belonging to the genus Callyspongia (C. fibrosa)
Summary
The broadness in the discovery of natural marine products have increased over the last two decades with the number of new compounds discovered per year increasing [1]. Various chemical and biological investigations, for the different extracts of the undescribed species of the genus Amphimedon, can be found in previous literature. These investigations confirmed that the genus, Amphimedon, is rich in different classes of natural products. Biological investigations of the alkaloids and fattymarine acids metabolites from the marine sponges the some genusofAmphimedon, their associated microorganisms, isolated from. Amphimedon have shownofthat these compounds possess antimicrobial [22], biological activities, and their places of collection whenever applicable. Discovery of the natural metabolites from the four sponges viridis, compressa, complanata, and terpenensis were reported in previous literature
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