Natural product-derived building blocks for combinatorial synthesis. Part 1. Fragmentation of natural products from myxobacteria

Abstract

Novel and unique chiral building blocks of high structural diversity were obtained by selective chemical fragmentation of natural products from myxobacteria. Subsequent modification reactions provided primary alcohol and carboxylic acid derivatives, which are suitable for the construction of combinatorial chemical libraries. The single SPOT synthesis of a hybrid structure on a polypropylene membrane was employed to demonstrate the chemical recombination of such rare building blocks on a micro-scale.