Abstract
Natural products have been a source of medicinal agents since thousands of year and remarkable numbers of modern drugs have been derived from natural sources, predominantly based on their knowledge available in traditional medicine. The modern natural product research is undergoing a revolution due to recent advancements in combinatorial biosynthesis, microbial genomics and screening processes. The total synthesis of complex natural products has long presented a big challenge to the synthetic chemist, and led to considerable advances in synthetic methodology. To continue to be competitive with other drug discovery methods, natural product research needs to continually improve the speed of the screening, isolation, and structure elucidation processes, as well addressing the suitability of screens for natural product extracts and dealing with issues involved with large-scale compound supply.
Highlights
Natural products have been a source of medicinal agents since thousands of year and remarkable numbers of modern drugs have been derived from natural sources, predominantly based on their knowledge available in traditional medicine
The pharmacophore consists of a peroxide within a 1, 2, 4-trioxane configuration, the presence of which has led to several suggestions of how these antimalarials might work [11]
There is no doubt that plants are among the most perfect “natural laboratories” for the synthesis of various molecules ranging from simple skeleton to highly complex chemical structures
Summary
Natural products have been a source of medicinal agents since thousands of year and remarkable numbers of modern drugs have been derived from natural sources, predominantly based on their knowledge available in traditional medicine. Plant products play an imperative role in the health care systems of the remaining 20% of the population, mainly residing in developed countries, and at least 119 chemical substances, derived from 90 plant species, can be considered as important drugs at present in use in one or more countries. Of these 119 drugs, 74% were discovered as a result of chemical studies aimed at the isolation of the active substances from plants used in traditional medicine [1]. The developments of antimalarial and anticancer drugs using some of the lead compounds (Phytoconstituent) isolated from natural source are discussed below
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