Abstract
The present paper describe the production and characterization of novel collagen films containing propolis encapsulated in chitosan nanoparticles, for biomedical applications such as cutaneous wound healing. Structural and morphological details were investigated by ATR FTIR spectroscopy, SEM and nanoindentation measurements, revealing the collagen fibers aligned in a quasi-parallel distribution, which might be favorable for biomedical applications. Moreover, the vibrational marker bands of propolis were well preserved in the final polymeric mixture, indicating the stability of bioactive compounds upon the encapsulation procedure. The antibacterial effect depends on the nanoparticles concentration in collagen film, the effect being more evident with respect to E. coli than S. aureus. The antioxidant capacity monitored by CUPRAC assay, indicated a synergic effect of chitosan nanoparticles matrix and propolis extract, incorporated in collagen films.
Highlights
The present paper describe the production and characterization of novel collagen films containing propolis encapsulated in chitosan nanoparticles, for biomedical applications such as cutaneous wound healing
The antibacterial effect depends on the nanoparticles concentration in collagen film, the effect being more evident with respect to E. coli than S. aureus
It has to be noticed that the marker bands of propolis are well preserved in the final polymeric mixture, indicating that the bioactive compounds are stable upon the encapsulation procedure
Summary
The present paper describe the production and characterization of novel collagen films containing propolis encapsulated in chitosan nanoparticles, for biomedical applications such as cutaneous wound healing. The antioxidant capacity monitored by CUPRAC assay, indicated a synergic effect of chitosan nanoparticles matrix and propolis extract, incorporated in collagen films. In the light of recent developments in the wound management field, the aim of our work was to prepare and to investigate the structural, morphological and antibacterial properties of novel collagen film with chitosan nanoparticles entrapping propolis extract, as an advanced and eco-friendly wound dressing device. A mixture of propolis extract and Arabic gum was added gradually, by vigorous stirring, to chitosan solution, and glutaraldehyde cross-linking agent was injected by syringe, under continuous stirring, allowing nanoparticles formation. The films were kept in a sandwich system, between two glass plates, manually pressed
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