Abstract
EVIDENCE has been obtained for the existence, in certain normal guinea pigs, of a state of delayed iso-hypersensitiveness to a heritable factor present in the serum of other normal guinea pigs. This condition, which arises at about 2 months of age, appears analogous to the long known1 natural existence of circulating iso-antibodies to heritable blood group antigens in other species. Delayed-type hypersensitivity to isophile antigens may, of course, be experimentally induced (cf. ref. 2), but its spontaneous occurrence seems not to have been suspected.
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