Abstract
Marine fungi are species of fungi which live in estuaries environment and marine environment. These species are found in common habitat. Marine fungi are rich in antimicrobial compounds such as anthrones, cephalosporins, peptides, steroids. These compounds which are derived mainly focused in the area of anti-inflammatory, anti-oxidant, anti-fungal, anti-microbial, anti-fouling activity. Bioactive terpene compounds are produced by marine fungi and marine derived fungi can produce sclerotides, trichoderins. Marine fungi have become the richest sources of biologically active metabolites and structurally novel in the marine environment. In a recent study the marine derived fungi dichotomomyces cejpii exhibits activity towards cannabinoid which is used to treat alzheimer dementia. Aspergillus unguis showed significant acetyl cholinesterase besides its anti-oxidant activity. These acts as a promising intent for discovery of pharmaceutically important metabolites like alkaloids, peptides. Computational (in silico) strategies have been developed and broadly applied to pharmacology advancement and testing. This review summarizes the bioactive compounds derived from marine fungi in accordance with the sources and their biological activities.
Highlights
To date there are about 100,000 fungal species, it is expected about one million species that are to be present
Carbonarones A (1) and B (2), were acquired from the marine-fungi Aspergillus carbonarius detached from the marine residue gathered at Weizhou island of China
Researchers scanned for new secondary metabolites from ocean inferred growth strain FKJ-0025 and found two new compounds, sarcopodinols A (1) and B (2), together with a known compound, SF-227. This is the principal report of secondary metabolites separated from family Sarcopodium
Summary
To date there are about 100,000 fungal species, it is expected about one million species that are to be present. In spite of the fact that bio activities of secondary metabolites from marine fungi unveil clinical targets; they are not well constituted for pipelines of drugs and none of them is available [17]. In excess of 180 bioactive secondary metabolites got from deep ocean fungi have been reported These natural metabolites obtained are generally organic and compounds like Pencillium, Polyketides is largely discovered. Such methods have seen frequent use in the discovery and optimization of physicochemical characterization [21, 22]
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