Abstract
To better understand the pathogenesis of Sezary cells, distinguish them from reactive skin-infiltrating T-cells and improve disease treatment, efforts have been made to identify molecular targets deregulated by the malignant process. From immunophenotypic analysis and subtractive differential expression experiments to pan-genomic studies, many approaches have been used to identify markers of the disease. During the last decade several natural killer (NK) cell markers have been found aberrantly expressed at the surface of Sezary cells. In particular, KIR3DL2/CD158k, expressed by less than 2% of healthy individuals CD4
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