Abstract
Natural killer (NK) cell activity was found to be above normal levels in patients with common variable immunodeficiency (CVID), whereas no NK cell abnormality was found in patients with selective IgA deficiency. The lytic activity of a given amount of peripheral blood lymphocytes was about five times higher in CVID patients than in controls when either K562, Molt 4, or Chang cells were used as targets. Interferon boosted the activity in patients and controls to about the same degree. NK activity was positively correlated to the number of circulating T8 + cells. Dysfunction of T cells, increase in suppressor cell function, and hyperactivity of NK cells in CVID may have a common background, possibly an abnormality related to interferon production.
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