Abstract
Abstract Epithelial Ovarian Carcinoma (EOC) is the sixth most common malignancy in women and the leading cause of death of gynecological cancer in the world. EOC has a predisposition to metastasis to the peritoneal cavity. A late stage peritoneal dissemination results in ascites and high mortality rates with an overall survival of 20 to 30 percent at 5 years after surgery. While many studies in the literature address the issue of distant metastasis, the biology of peritoneal tumor spread in advanced ovarian cancer is not clear. Development of peritoneal carcinomatosis involves well-defined critical steps, including cell shedding and transport, interaction and adhesion to the mesothelial layer, and colonization of and proliferation into the sub-mesothelial microenvironment. It is now appreciated that there must be an initiation of a pre-metastatic niche within the target organ, one that facilitates the survival of tumor cells in a non-receptive organ. We think that a dual approach looking at oncogenomics a...
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