Abstract
Background:Asymptomatic solitary meningiomas are typically managed with clinical and radiographic follow-up. Multiple meningiomas represents a clinical entity distinct from solitary meningiomas and can be sporadic, radiation-induced, associated with neurofibromatosis, or exhibit other familial inheritance. The growth rate for multiple meningiomas is not known and therefore management of these complicated patients can be difficult.Methods:A retrospective chart review was performed on 12 patients with a total of 55 meningiomas. Patients with neurofibromatosis were not included. Serial enhanced magnetic resonance imaging was used to determine tumor growth rates. Treatment history was also reviewed and included for analysis.Results:Analysis of all 55 tumors demonstrated an average rate of growth of 0.46 cm3/year (range: −0.57-2.94 cm3/year). In the 23 tumors that received no treatment, the average rate of growth was 0.34 cm3/year (range: −0.03-1.8 cm3/year). Ten of the 23 tumors that received no treatment had no history of cranial irradiation. This group demonstrated a growth rate of 0.44 cm3/year (range: −0.01-1.8 cm3/year). Linear regression analysis did not yield any significant relationship between tumor burden and rates of growth.Conclusion:Tumor growth rates in patients with multiple meningiomas did not appear to be higher than reported rates for incidentally found solitary meningiomas. As such, asymptomatic multiple meningioma patients should be managed with clinical and radiographic follow-up.
Highlights
Asymptomatic solitary meningiomas are typically managed with clinical and radiographic follow‐up
Meningiomas are the most common brain tumors, representing approximately 35% of all brain tumors diagnosed in the United States.[3]
Existing data suggests that meningiomas generally fall into three groups: Those that do not grow, those that exhibit linear growth, and those that exhibit exponential growth.[2,7]
Summary
A retrospective chart review was performed on 12 patients with a total of 55 meningiomas. Serial enhanced magnetic resonance imaging was used to determine tumor growth rates. Treatment history was reviewed and included for analysis. A retrospective chart review was performed on patients treated at NorthShore Neurologic Institute between 1990 and 2010 to identify patients with more than one meningioma. Thirteen patients were identified with a total of 69 meningiomas. One patient had a history of NF type 2 and was excluded for the purposes of our study. The remaining 12 patients had 55 tumors. While one had no treatment during the period of follow‐up. Seven of the eleven had surgical treatment of one or more tumors
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