Natural history of intraductal papillary mucinous neoplasms following solid organ transplant

Abstract

Background: Solid organ transplant (SOT) survival rates have improved with advances in immunosuppressive medications. Chronic immunosuppressive exposure, however, increases the risk of developing malignancies due to the loss of immune surveillance and/or the carcinogenic effects of these medications. Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic lesions that carry malignant potential. The long-term prospective for malignant transformation of IPMN in the setting of chronic immunosuppressive therapy is unclear. In this study, we aim to evaluate the natural history of IPMNs in immunosuppressed transplant patients.