Abstract
A longitudinal study was made of the presence of Candida species and yeasts in infants from the day of birth until 1-yr-old, diagnosed by the culture of oral swab samples. The isolation rate of Candida rose from 5.7 per cent neonatally to 14.2 per cent on discharge from hospital at 7 days. The prevalence increased sharply when the infants returned home, reaching 82 per cent at 4 weeks of age, but then slowly declined to 50 per cent at 1 yr. At 4 weeks, yeasts were isolated from an additional 14 per cent of infants. The predominant species was C. albicans with relatively few isolates of C. tropicalis, C. parapsilosis and C. pseudotropicalis. Estimates of neonatal serum antibody to C. albicans showed no correlation with initial or subsequent oral colonization by this organism.
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