Natural film based on collagen and sulfated polysaccharide for antiplatelet effects

Abstract

Although several properties of collagen have been explored, the blend formation with sulfated polymers is poorly explored. Antiplatelet effects can be achieved after the formation of this type of blend. In this work, a film formed by collagen and sulfated polysaccharide and their properties were analyzed. Five blends were produced, blend with collagen (10 mg/g) and 0, 5, 10, 20, and 25% of the sulfated polysaccharide. No changes amine (I, II, and III) vibrations alterations were observed, where the collagen structure remained unchanged. In addition, it was also observed the presence of sulfoxide groups related to the presence of sulfated polysaccharides. The samples have the same thermal degradation profile. Additionally, the stability of the film is up to 100 °C, characterized by the loss of water from the structure caused by the break-up of the blend. Also, it was verified that the adhesion of platelets to the collagen decreases with the presence of sulfated polysaccharide. The synthesized material presents a potential for application as an anti-thrombogenic agent, besides being biodegradable and biocompatible.