Natural dietary compound naringin inhibits glioblastoma cancer neoangiogenesis

Sonia Aroui,Hamadi Fetoui,Abderraouf Kenani

doi:10.1186/s40360-020-00426-1

Sonia Aroui, Hamadi Fetoui + Show 1 more

Open Access

https://doi.org/10.1186/s40360-020-00426-1

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Abstract

BackgroundFlavonoids, which existed nearly in all fruits and vegetables, are considered as a class of plant-secondary metabolites with a polyphenolic structure and have properties with health-improving potential. Yet, not so many experimental focus on the benefits of flavonoid in vivo after external application. Here we assessed the impacts of naringin in vitro and in vivo in the human glioma U-87 cells implanted into athymic mice.MethodsTumor size and animal survival time were followed in naringin-treated mice bearing subcutaneous gliomas. To define the effects of naringin on angiogenesis, in vitro, tube formation and migration were assayed using endothelial HUVEC cell line.ResultsLow concentration of naringin remarkably inhibited tubulogenesis and reduced cell invasion. Moreover, naringin has been shown to have a toxicity effect on U-87 cells in a dose-dependent way. Furthermore, naringin administration (120 mg/kg/day) applies serious anti-cancer belongings on glioblastoma, as demonstrated by a slow cancer progression.ConclusionsOur study has provided the first evidence on the antitumor effect of naringin, which is somehow due to the inhibition of invasion and angiogenesis.

Highlights

Flavonoids, which existed nearly in all fruits and vegetables, are considered as a class of plantsecondary metabolites with a polyphenolic structure and have properties with health-improving potential
In vivo anti-tumor efficacy of naringin Glioblastoma was chosen as a model of cancer to investigate the anti-tumor efficacy of naringin
The analysis was seated on day 3, subsequently to xenograft, as shown in the method section

Summary

Introduction

Flavonoids, which existed nearly in all fruits and vegetables, are considered as a class of plantsecondary metabolites with a polyphenolic structure and have properties with health-improving potential. Naringin (4′, 5, 7trihydroxy flavanone-7-rhamnoglucoside), a glycone form of naringenin found in most citrus fruits [3] This flavonoid has been reported to own numerous biological effects important to human health and reduce cardiac hypertrophy by inhibiting oxidative stress and inactivating c-Jun nuclear kinase (JNK-1) protein in type I diabetes [4]. It ameliorates sodium arsenite-induced renal and hepatic toxicity in rats by modulating the activities of KIM-1, caspase-3, TGF-β and TNF-α [5]. It possesses the anti-apoptotic activity of hepatocellular carcinoma HepG2 cells [7] and prostate DU145

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