Abstract
Excessive alcohol intake is a direct cause of alcoholic liver disease (ALD). ALD usually manifests as fatty liver in the initial stage and then develops into alcoholic hepatitis (ASH), fibrosis and cirrhosis. Severe alcoholism induces extensive hepatocyte death, liver failure, and even hepatocellular carcinoma (HCC). Currently, there are few effective clinical means to treat ALD, except for abstinence. Natural compounds are a class of compounds extracted from herbs with an explicit chemical structure. Several natural compounds, such as silymarin, quercetin, hesperidin, and berberine, have been shown to have curative effects on ALD without side effects. In this review, we pay particular attention to natural compounds and developing clinical drugs based on natural compounds for ALD, with the aim of providing a potential treatment for ALD.
Highlights
Alcohol liver disease (ALD), a liver disease caused by long-term heavy alcohol intake, is the leading cause of chronic liver disease (CLD), especially in Europe and America (Hosseini et al, 2019)
In the field of ALD research, clinical trials are still needed for systematic reviews
From the 1940s to 2010, 65% of anti-bacterial small molecules and 41% of anticancer small molecule drugs were derived from natural compounds and derivatives
Summary
Alcohol liver disease (ALD), a liver disease caused by long-term heavy alcohol intake, is the leading cause of chronic liver disease (CLD), especially in Europe and America (Hosseini et al, 2019). Natural compounds have enormous potentials to be developed as therapeutic drugs for ALD.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
