Abstract
Breast cancer is the most common cancer among American women. Any woman can be affected by breast cancer, with risk for the disease increasing with age. Risk for breast cancer is also exacerbated in women who have certain genetic alterations. Mutations in the BRCA1 and BRCA2 genes predispose women to breast and ovarian cancer, and are increasingly recognized in prostate and pancreatic cancers (1-3). In Caucasian and Asian ethnicities BRCA mutations are associated with basal-type/triple-negative disease. However this association between BRCA gene mutations and basal/triple-negative disease has been understudied in other ethnicities (4-6). The incidence and mortality of breast cancer of Hispanics and Native Americans are lower than other ethnicities; however they are underrepresented in epidemiological and clinical studies. Further, it is known that common recurrent mutations in BRCA1 and BRCA2 genes exist in Hispanic/Latino communities which account for 35-45% of mutation carriers (7, 8). The objective of our study is thus to investigate triple-negative disease and BRCA gene mutations in Hispanic women.
Highlights
INTRODUCTION & PROJECT AIMSBreast cancer is the most common cancer among American women
All subjects will be asked to permit the release of a copy of their pathology report
Upon receipt of consent and saliva sample, the PI or an authorized BTRIS user will register the subject into the BTRIS system, and barcode the saliva sample with a coded ID number
Summary
Breast cancer is the most common cancer among American women. Any woman can be affected by breast cancer, with risk for the disease increasing with age. Mutations in the BRCA1 and BRCA2 genes predispose women to breast and ovarian cancer, and are increasingly recognized in prostrate and pancreatic cancers (13). In Caucasian and Asian ethnicities BRCA mutations are associated with basaltype/triplenegative disease. This association between BRCA gene mutations and basal/triplenegative disease has been understudied in other ethnicities (46). The incidence and mortality of breast cancer of Hispanics and Native Americans are lower than other ethnicities; they are underrepresented in epidemiological and clinical studies. The objective of our study is to investigate triple negative disease and BRCA gene mutations in Hispanic women
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have