Abstract
Nationwide outcomes of simultaneous resection of primary colorectal cancer and synchronous liver metastases
Highlights
After controlling for known clinical confounders, NAFLD remained significantly associated with the risk of IHR (HR = 1.83, 95%CI = 1.08-3.10, p = 0.02, Figure 1)
Clinical characteristics and total inpatient oral morphine equivalent (OME) use and discharge prescription amounts were downloaded from electronic records for patients who underwent hepatectomy at a single institution between 3/2016-12/2017
Lower last-24-hour inpatient opioid use was associated with lower discharge prescription OME
Summary
DWR were 35%, 26%, and 9% respectively. After controlling for known clinical confounders, NAFLD remained significantly associated with the risk of IHR (HR = 1.83, 95%CI = 1.08-3.10, p = 0.02, Figure 1). NAFLD (HR = 0.19 95%CI=0.05-0.78, p = 0.02), tumor size >5cm (HR = 1.87, 95%CI = 1.15-3.05, p = 0.01), and hepatic artery infusion chemotherapy (HR = 1.59, 95%CI = 1.05e2.41, p = 0.03) were independently associated with risk of EHR. NAFLD was not associated with OS (HR = 0.91, 95%CI = 0.59e1.40, p = 0.665), tumor size > 5cm (HR = 1.73, 95%CI = 1.28e2.34, p 200 (HR = 2.28, 95%CI = 1.35e3.86, p 3 (HR = 2.10, 95%CI = 1.56e2.83, p < 0.01) were associated with OS on univariate analysis. NAFLD was not associated with OS, it was an independent predictor of time to IHR. The presence of NAFLD offers prognostic information for risk of timing and location of recurrent disease
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