Nationwide incidence of patients hospitalized for a mitral regurgitation: Patient characteristics and temporal trends in France 2006–2016

Abstract

In 2006, the prevalence of mitral regurgitation has been estimated at 9.3% in the US population over 75 years of age. The main etiology of mitral regurgitation is degenerative with valve prolapses and ischaemic in developed countries. Estimate the annual incidence of patients hospitalized for non-rheumatic mitral regurgitation (nRMR) in France, and describe their characteristics and the temporal trends. All patients hospitalized for nRMR management in France between 2006 and 2016 were identified using data from the national hospital discharge database (PMSI-MCO) integrated into the national health data system (SNDS). The index stay was defined as the first stay of the year in which the patient are hospitalized for valvular heart disease. Stays whose principal or related diagnosis was mitral valve insufficiency (ICD10-I340) or mitral valve prolapse (ICD10 - I341) were included in this study. Surgical valve procedures were identified from the French medical classification for clinical procedures. The socio-demographic, medical and surgical characteristics of patients and temporal trends from 2006 to 2016 were described. In 2016 5,864 patients were hospitalized for a nRMR, 32% of whom had associated ischemic heart disease and 12% had mitral prolapse, identifiable by the SNDS; 59% were male and the average age was 68 years. A total of 17.9% of these patients had a multivalvular heart disease. The case-fatality rate at 1 year of the index stay was 8.5%. The incidence of patients hospitalized for nRMR increased by 14% between 2006 and 2016, and was 9.1/100,000 PY. Moreover, in 2016, 73% of patients hospitalized for nRMR were operated in the year following the index hospital stay. The incidence of patients hospitalized for nRMR increased in recent years. This upward trend is expected to continue with the current development of percutaneous mitral valve procedures.