National trends in cholangiocarcinoma in the United States (US): 2000-2014.

Abstract

e13056 Background: Cholangiocarcinoma (CCA) arise from the epithelial cells of the intrahepatic and extrahepatic bile ducts. Although rare in the US, they are highly lethal because most are locally advanced at presentation. The incidence of CCA has increased over time. This study aims to estimate the characteristics, outcomes, and cost burden of patients hospitalized for CCA by using a large national database. Methods: The Nationwide Inpatient Sample (NIS) database was used to obtain data from 2000-2014. The NIS contains data from over 7 million hospital stays in the US per year generalizable to the American population. The NIS was queried for ICD-9 codes for primary diagnosis of CCA with 155.1 [Malignant Neoplasm of Intrahepatic Ducts (MNID)] and 156.1 [Malignant Neoplasm of Extrahepatic ducts (MNED)]. Information for total number of hospitalizations, mortality, and hospital charges was evaluated. Results: The number of hospitalizations for MNID increased from 2,599 in to 4,840 (p < 0.001) from 2000 to 2014. The number of hospitalizations for MNED decreased from 2,529 to 2,350 but was not statistically significant. Inpatient mortality of MNID decreased from 12.98% to 8.57% (p < 0.05%). Inpatient mortality of MNED decreased from 7.46% to 5.11% but was not statistically significant. Mean charges for MNID increased from $27,779 to $79,096 (p < 0.001). Mean charges for MNED increased from $34,212 to $89,852 (p < 0.001). Conclusions: This study demonstrates that the number of hospitalizations for MNID has increased by 86% from 2000 to 2014. This number continues to rise. However, inpatient mortality of MNID is decreasing. These findings show that the incidence of cholangiocarcinoma of the intrahepatic subtype is increasing and more study is required to investigate why this is so.