Abstract
ObjectiveTo evaluate the efficacy of nasal continuous positive airway pressure (nCPAP) in decreasing respiratory distress in bronchiolitis.DesignRandomized controlled trial.SettingTertiary-care hospital in New Delhi, India.Participants72 infants (age < 1y) hospitalized with a clinical diagnosis of bronchiolitis were randomized to receive standard care, or nCPAP in addition to standard care, in the first hour after admission. 23 parents refused to give consent for participation. 2 infants did not tolerate nCPAP.InterventionThe outcome was assessed after 60 minutes. If nCPAP was not tolerated or the distress increased, the infant was switched to standard care. Analysis was done on intention-to-treat basis.Main outcome measuresChange in respiratory rate, Silverman-Anderson score and a Modified Pediatric Society of New Zealand Severity Score.Results14 out of 32 in nCPAP group and 5 out of 35 in standard care group had change in respiratory rate ≥10 (P=0.008). The mean (SD) change in respiratory rate[8.0 (5.8) vs 5.1 (4.0), P=0.02] in Silverman-Anderson score [0.78 (0.87) vs 0.39 (0.73), P=0.029] and in Modified Pediatric Society of New Zealand Severity Score [2.5 (3.01) vs. 1.08 (1.3), P=0.012] were significantly different in the nCPAP and standard care groups, respectively.ConclusionnCPAP helped reduce respiratory distress significantly compared to standard care.
Highlights
Intervention: The outcome was assessed after 60 minutes
Conclusion: nCPAP helped reduce respiratory distress significantly compared to standard care
Bubble Continuous positive airway pressure (CPAP) was delivered in the pediatric ward with a Gregory circuit [5,6]
Summary
To evaluate the efficacy of nasal continuous positive airway pressure (nCPAP) in decreasing respiratory distress in bronchiolitis. Participants: 72 infants (age
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