Abstract
In an attempt to find effective analgesics which are nontoxic and nonaddictive, considerable attention has been given to esters of tertiary y-piperidoles. At the present t~me, prodine (i, 3-dimethyl-4-phenyl-4-propionoxypiperidine) and promedol (i, 2,5-trimethyl-4phenyl-4-propionoxypiperidine) are widely used in medicine [3, 8]. It has been shown that the stereosiomeric a- and B-prodine, and also the stereoisomeric promedol, isopromedol, and a-promedol differ considerably from each other in analgesic activity [7, 8]. At the present time, propionic acid amides with an aryl or y-piperidyl substituent are
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