Abstract
Vitiligo is an acquired depigmentation disorder with great impact on patient's appearance and quality of life. Till date, the etiology of vitiligo remains elusive, which makes it difficult to have curative therapies. Photochemotherapy (psoralen and ultraviolet A) long remained the mainstay of treatment of vitiligo, until the advent of narrowband ultraviolet B (NBUVB) phototherapy, which revolutionized the treatment of vitiligo with better results, tolerability and side effect profile than the former. It has been used favorably, both alone as well as in combination with other agents like topical calcineurin inhibitors, Vitamin-D analogs, oral and topical corticosteroids, antioxidants, etc. Recently, various new phototherapeutic modalities like excimer light and laser have come into use with encouraging results. In this article, we review the journey of NBUVB so far and highlight the current status of other new phototherapy modalities in the treatment of vitiligo.
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