Abstract
Mushrooms have remained an eternal part of traditional cuisines due to their beneficial health potential and have long been recognized as a folk medicine for their broad spectrum of nutraceuticals, as well as therapeutic and prophylactic uses. Nowadays, they have been extensively investigated to explain the chemical nature and mechanisms of action of their biomedicine and nutraceuticals capacity. Mushrooms belong to the astounding dominion of Fungi and are known as a macrofungus. Significant health benefits of mushrooms, including antiviral, antibacterial, anti-parasitic, antifungal, wound healing, anticancer, immunomodulating, antioxidant, radical scavenging, detoxification, hepatoprotective cardiovascular, anti-hypercholesterolemia, and anti-diabetic effects, etc., have been reported around the globe and have attracted significant interests of its further exploration in commercial sectors. They can function as functional foods, help in the treatment and therapeutic interventions of sub-optimal health states, and prevent some consequences of life-threatening diseases. Mushrooms mainly contained low and high molecular weight polysaccharides, fatty acids, lectins, and glucans responsible for their therapeutic action. Due to the large varieties of mushrooms present, it becomes challenging to identify chemical components present in them and their beneficial action. This article highlights such therapeutic activities with their active ingredients for mushrooms.
Highlights
Introduction published maps and institutional affilMushrooms have been present on earth for ages and are an important, indispensable part of global cuisine
Jesus et al evaluated the wound healing effect of a β-D-glucan from the edible mushroom Piptoporus betulinus [14]. They found that the β-D-glucan derived showed promotion of viability of caco-2 cells confirmed by MTT
The Beta-glucan content derived from mushroom Sparassis crispa showed wound healing action on diabetic wounds [16]
Summary
Mushrooms have been shown to have the potential for wound healing application. The polysaccharides derived from the Gracilaria lemaneiformis speed up the wound closure rate, improving the epithelial layer thickness and collagen deposition [12]. Regulating the wound healing activity by increasing the cell proliferation causes accelerated wound healing [13]. Jesus et al evaluated the wound healing effect of a β-D-glucan from the edible mushroom Piptoporus betulinus [14]. They found that the β-D-glucan derived showed promotion of viability of caco-2 cells confirmed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay. It was seen that the polysaccharide derived from mushrooms sped up the in vitro wound healing process via migration of epithelial intestinal cell migration. The Beta-glucan content derived from mushroom Sparassis crispa showed wound healing action on diabetic wounds [16].
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