Abstract
A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-( p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with ‘time-resolved’ and pH independent properties.
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