Abstract
A 57-year old man became affected by excessive daytime sleepiness. Thereafter, he had difficulty in moving his left limbs and began to walk slowly. He had no particular past or family history. He had taken no medications. Neurologically, Parkinsonism was present. Sleep examinations revealed that the diagnostic criteria of narcolepsy without cataplexy were fulfilled. The orexin level in the cerebrospinal fluid (CSF) was undetectable (>40 pg/mL). HLA DR2 was negative. These factors led to a diagnosis of narcolepsy due to Parkinson’s disease (PD). This is the first clear case of narcolepsy due to PD presenting a decreased CSF-orexin level.
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