Abstract
Our previous research has shown that yolk granules can act as a unitary carrier of lipophilic substances. In this study, the Ca2+ content was adjusted using (NaPO3)6 to control the reassembly of yolk granules for curcumin encapsulation to generate yolk granule-curcumin nanoparticles (Gra-Cur NPs). (NaPO3)6 reduced the particle hydrodynamic diameter (Dh). Dissociated granules had the same protein profile as untreated granules, indicating that no new protein subunits were produced. Hydrophobic interaction was the main force of curcumin binding to yolk granules, and curcumin is amorphous after encapsulated. Gra-Cur NPs had excellent thermal and storage stability. Flow cytometry revealed that the rate of HT-29 cell apoptosis and curcumin absorption of encapsulated curcumin was higher than that of curcumin dissolved in DMSO, with smaller Dh. The findings of this study will allow for the development and implementation of bioactive compounds as novel carriers.
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