Abstract
Naphthalimide-Borondipyrromethene (NI-BODIPY) dyads, bearing NI unit on the meso and styryl positions of BODIPY core were designed and subjected to photophysical, in vitro cell imagining and antimicrobial activity studies. The identities of synthesized compounds (3-5) were confirmed by using FT-IR, 1H, 13C NMR and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The structure of the NI-BODIPY dyad (3) was also characterized by means of X-ray diffraction. Spectroscopic properties of dyad systems were explored in detail via UV-vis absorption and fluorescence emission spectroscopies. Mono- and distyryl- derivatives (4 and 5) revealed a substantial conjugation effect manifested by an expected bathochromic shift in absorption and emission spectra relative to dyad 3. The use of NI-BODIPYs for live cell lines is demonstrated by flow cytometry and confocal microscopy in which compound 3 produced the brightest fluorescence in confocal microscopy. Furthermore in vitro antimicrobial activities were evaluated on Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. Noticeably, the distyryl- derivative 5 functionalized with three NI units displayed superior antibacterial activity against both E. coli and S. aureus with MIC values of 76 and 110 μM, respectively. Naphthalimide decorated BODIPY dyads have been proposed as both antibacterial and cell imaging agents.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
