Abstract
Two new naphthalenones, corynenones A and B (1 and 2), and one new depsidone, corynesidone E (3), together with one known depsidone, corynesidone A (4) and two known diphenyl ethers, corynethers A (5) and B (6), were isolated from the sponge-derived fungus Corynespora cassiicola XS-20090I7. Their structures including absolute configurations were determined by spectroscopic data and electronic circular dichroism (ECD) spectra. Compounds 4 and 5 showed cytotoxicity against human promyelocytic leukemia HL-60 and human cervical carcinoma HeLa cell lines.
Highlights
Marine fungi have played an important role for drug discovery as a source of structurally unique and biologically active secondary metabolites
The further chemical investigation of this strain led to the isolation of two new naphthalenones, corynenones A and B (1 and 2), and one new depsidone, corynesidone E (3), together with three known compounds, corynesidone A (4) [6], corynethers A (5) [6]
The six nonprotonated centers were separated into two categories: an α,β-unsaturated ketone at δC 202.1, five aromatic carbons at δC 157.9, 157.3, 142.7, 134.2, and 110.8. These spectroscopic features revealed that the parent skeleton of 1 was naphthalenone, and was very similar to 4-hydroxyscytalone previously isolated from Pyricularia oryzae Cavara [8]
Summary
Marine fungi have played an important role for drug discovery as a source of structurally unique and biologically active secondary metabolites. Sponge-derived fungi take up a large proportion of marine fungal diversity, and produce numerous new bioactive compounds which display promising biological and pharmacological properties, such as antiviral, antibacterial, antitumor, antifouling, anti-inflammatory, and immunomodulatory activities [1,2,3,4]. We reported 12 new chromone derivatives isolated from the sponge-derived fungus Corynespora cassiicola. The further chemical investigation of this strain led to the isolation of two new naphthalenones, corynenones A and B (1 and 2), and one new depsidone, corynesidone E (3), together with three known compounds, corynesidone A (4) [6], corynethers A (5) [6]. We report the isolation, structure elucidation, and biological activities of these compounds.
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