Naphthalene substituted benzo[c]coumarins: Synthesis, characterization and evaluation of antibacterial activity and cytotoxicity

Mrugesh Patel,Kaushal Patel

doi:10.1515/hc-2019-0024

Mrugesh Patel, Kaushal Patel

Open Access

https://doi.org/10.1515/hc-2019-0024

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Journal: hc	Publication Date: Dec 31, 2019
Citations: 11	License type: CC BY 4.0

Affiliation: Charotar University of Science and Technology

Abstract

AbstractNovel congeners of naphthalene substituted benzo[c]coumarins (2a-f) were synthesized by reaction of various 3-coumarinoyl methyl pyridinium bromide salts (1a-d) with a selected set of acetyl naphthalene in the presence of sodium acetate in refluxing glacial acetic acid. Structures of the synthesized compounds were confirmed by elemental analysis and by various spectroscopic techniques such as 1H-NMR, 13C-NMR, DEPT, and MS spectral data. Synthesised compounds were screened for antibacterial activity and cytotoxicity against different human cancer cell lines including cervix cancer (HeLa), breast cancer (MCF-7) and lung cancer (A549) using tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell viability assay. Although with varying degrees, a significant growth inhibitory and cytotoxic effects were observed on all three cancer cell lines. Compounds 2b and 2e showed significant growth inhibitory and cytotoxicity against aforementioned cancer cell lines.

Highlights

Compounds 2b and 2e showed significant growth inhibitory and cytotoxicity against aforementioned cancer cell lines
Synthesised compounds were screened for antibacterial activity and cytotoxicity against different human cancer cell lines including cervix cancer (HeLa), breast cancer (MCF-7) and lung cancer (A549) using tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell viability assay
Patel.: Naphthalene substituted benzo[c]coumarins 147 evaluated for cytotoxicity as well as anti-bacterial activity

Summary

Introduction

Compounds 2b and 2e showed significant growth inhibitory and cytotoxicity against aforementioned cancer cell lines. The synthesized compounds were investigated for their antibacterial activity and cytotoxicity on A549 human lung adenocarcinoma, HeLa human cervical adenocarcinoma, and MCF-7 human breast adenocarcinoma cell lines.

Results

Conclusion