Abstract
Histone chaperones are a class of proteins that bind and transport histones, preventing their chaotic aggregation when forming nucleosomes. Histone chaperones of the NAP (Nucleosome Assembly Protein) family contain a highly conserved central NAP domain, which is necessary for histone binding and nucleosome assembly. They are an essential component in creating and maintaining the eukaryotic chromatin dynamics on which the transcription of many genes depends. The review considers the NAP family of proteins and its specific representatives: NAP1, NAP2, and CG5017/Hanabi. Since they are canonical histone transporters providing effective chromatin remodeling, NAP family proteins are involved in neuronal differentiation, spermatogenesis, and long-term memory formation, which indicates the importance of this family in ontogenesis.
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