‘NanoViroSan’ antimicrobial composite, designed for emergency epizootic situations and safe usage in ecological pig farming

Abstract

Analytical data of preclinical and clinical trials of the experimental veterinary composite drug ‘NanoViroSan’ (containing Methisazone, Silgeran and magnesium nanooxide) on laboratory models of Aujeszky’s (AD) and Teschen (TD) diseases, circovirus infections (PCV 2) and actinobacillary pleuropneumonia (APP) as well as in enzootic foci of mixed infection of AD-PCV-APP and swine pox, are presented, respectively. At the level of statistical probability p ≤ 0.01–0.03 (n = 88), the absence of cytotoxic (n = 40, cultures of pig testicle cells and pig alveolar macrophages) and biotoxic effects (n = 48 guinea pigs) was proven, as well as high antimicrobial (viro- and bacteriostatic) activity of the drug in the concentration range (by Methisazone) of 1.0–4.0 mg/cm3. Intramuscular administration of the drug to male pedigree piglets in doses of 0.5 cm3/20 kg and 1.5 cm3/20 kg three times with an interval of a day made it possible to stop the carriage of the causative agents of mixed infection in the conditions of pig-breeding (n = 26, p ≤ 0.02). Similar treatment with the drug in a dose of 2 cm3/20 kg (by Methisazone) of a boar and five sows in another commodity farm made it possible to break the chain of vertical transmission of the causative agent of swine pox from the nucleus to offspring of the herd (n = 227, p ≤ 0.03). There conclusion was made regarding the perspective of experimental drug for bioprotection of pig farming in the conditions of martial law, as well, if additional research will be positive — as for the development of permaculture (‘green technologies’) in the field of pig breeding