Abstract
AbstractCarbon Nanotube (CNT) materials have superior properties in electric current carrying capacity, thermal conductivity, and thermal stability. Due to their structure with high aspect ratio, they have structural unusual toxicity and complicate safety issue in a target tissue. In optimized quantities with limited functionality, special type of CNT assembly such as “buckyball” can be used as a potential drug carrier of bioactive molecules and display with increased circulating time and acceptable functionality. We analyzed cytoxicity and inflammatory response following exposure of different size, mass, shape, and functionality of CNTs. We monitored the transport across skin, physiological perturbation of transepithelial electrical resistance (TER) during the exposure of different concentrations of CNTs. The mechanisms of CNTs’ toxicity are closely related to their structure, functional group, and surface charge on the molecule. We established the nanoscale toxicity of fullerenes of CNTs.
Highlights
Carbon nanotube material has become state of art since it was found biocompatible nanoscale source of delivery carrier in the body
Inflammatory and Cytotoxic Responses: Nitric oxide (NO) production following exposure of single walled carbon nanotubes (SWCNTs) to epithelial cells was dramatically increased as the concentration of SWCNTs increased (Figure 1A)
The Carbon Nanotube (CNT) molecule size is very important as we established that the skin epidermis layer 150-175 microns thick is combined layers of viable cells
Summary
Carbon nanotube material has become state of art since it was found biocompatible nanoscale source of delivery carrier in the body It was considered as cytotoxic and DNA mutant but in last 5 years it was investigated and its inert properties were capitalized as tiny nanomissiles hitting the target and releasing drugs at tissue site very precisely. The pitfalls of fullerene structures are that they have high binding and activation energies with likely possibility of binding with circulating free molecules such as hormones, enzymes, peptides and ions. These issues still make the CNT as suspects. The synergy of cytokines, nitric oxide production and cytotoxicity of alveolar cells were the main alterations caused during CNT exposure to alveolar cells
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