Abstract
Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer. Traditional pharmacotherapy has several limitations, such as inadequate therapeutic effect and side effects. Nanotechnology in drug delivery for liver fibrosis has exhibited great potential. Nanomedicine improves the internalization and penetration, which facilitates targeted drug delivery, combination therapy, and theranostics. Here, we focus on new targets and new mechanisms in liver fibrosis, as well as recent designs and development work of nanotechnology in delivery systems for liver fibrosis treatment.
Highlights
Chronic liver diseases (CLD) remain a major concern for public health around the world
Liver fibrosis is a common stage of various CLD, which is an important repair and pathological process caused by different etiologies, for instance, chronic viral infections, metabolic disorders, alcohol abuse, autoimmune insults, or cholestatic injury (Kisseleva and Brenner, 2021)
We focus on new targets and mechanisms, as well as recent designs and development work of nanotechnology in delivery systems for liver fibrosis treatment (Table 1)
Summary
Reviewed by: Zhengbao Zha, Hefei University of Technology, China Sung Hwan Ki, Chosun University, South Korea. Specialty section: This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences. Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer. Traditional pharmacotherapy has several limitations, such as inadequate therapeutic effect and side effects. Nanotechnology in drug delivery for liver fibrosis has exhibited great potential. Nanomedicine improves the internalization and penetration, which facilitates targeted drug delivery, combination therapy, and theranostics. We focus on new targets and new mechanisms in liver fibrosis, as well as recent designs and development work of nanotechnology in delivery systems for liver fibrosis treatment
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